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The Hidden Dangers of Lash Growth Serums

What do women want? The results of a 2014 Allergan survey showed 75% of women age 18-65 want longer, thicker, and darker eyelashes. It was that kind of overpowering demand from market research that drove Allergan to bring Latisse to market, their blockbuster lash growth serum that shows clinically significant changes to lash length, thickness, and darkness within 16 weeks of use.

But what is the real price of longer lashes? Latisse has well documented side effect potential. The main active ingredient bimatoprost is a chemical known as a prostaglandin analogue. Prostaglandins are chemical compounds found in naturally within almost all of our body’s tissue that are responsible for signaling inflammation within the body. As such, it’s no surprise that Latisse has been associated with common symptoms of inflammation around the eyes like swollen lids, redness, itching, and watering. FDA clinical testing show about 4% of Latisse users experience itching, redness, and watering, while a much lower number experience an allergic reaction causing the eyelids to swell. In addition to chronic irritation, Latisse has also been known to darken the eyelid skin and the color of the iris in people with light brown or hazel eyes, as well as potentially causing a sunken eye appearance by shrinking the layers of orbital fat around the eye socket.

It’s easy to brush off eye irritation as no big deal, but ocular surface dysfunction and chronic dry eye can take a permanent and lasting toll on your vision quality and ocular comfort. By promoting inflammation on the ocular surface, prostaglandin analogues can disrupt tear film production and expression at all layers.  Inflammation also promotes thickening of the oil secretions (meibum) expressed by the meibomian glands that run vertically through our top and bottom eyelids and are responsible for secreting the essential top oil layer of our tear film!

Inflammation causing dry eye can disrupt the ocular surface at every level via http://dryeyeandmgd.com/understanding-mgd/

Every time we blink, the meibomian glands secrete their oil. If that oil is too thick, it’s difficult for the eyelids to spread it evenly over the surface of the eye –more like toothpaste than olive oil. It may even get so thick that the oil blocks and backs up in the gland.  This will slowly but surely damage the gland permanently. If the meibomian glands atrophy or die off, the body is not able to repair the tissue and the gland becomes permanently nonfunctional.  The result is irreversible and often severe dry eye.

What’s gotten more press than the possible risk of permanent and irreversible dryness and ocular surface damage caused by Latisse or other prostaglandin analogue agents is the financial cost. At around $130 per month, prescription lash growth isn’t cheap. Over the counter alternatives have increasingly gained popularity due to this price point, but unfortunately the fact that they are not prescription leads some to falsely feel they must also be safer.  A list of the ingredients of one of the most popular over the counter lash growth serum, Rodan and Fields Lash Boost, shows a not-so-friendly potential dry eye culprit:

Ingredients: Water, Butylene Glycol, Hydroxyethylcellulose, Keratin, Hydrolyzed Keratin, Biotin, Sodium Hyaluronate, Isopropyl Cloprostenate, Octapeptide-2, Allantoin, Panthenol, Copper Tripeptide-1, Pantethine, Polypeptide-23, Cucurbita Pepo (Pumpkin) Seed Extract, Glycerin, Sea Water, Malus Domestica Fruit Cell Culture Extract , Hydrolyzed Glycosaminoglycans, Prunus Amygdalus Dulcis (Sweet Almond) Fruit Extract, Backhousia Citriodora Leaf Oil, Dipotassium Glycyrrhizate, Rhizobian Gum, Styrene/Acrylates/Ammonium Methacrylate Copolymer, Xanthan Gum, PVP, Lecithin, PEG-12 Dimethicone, Alcohol Denat, Chlorphenesin, Phenoxyethanol, Sorbic Acid, Sodium Hydroxide

What is Isopropyl Cloprostenate? It’s a synthetic prostaglandin analogue. As such it has the same method of action described above, and yes all the same potential side effect profile.  In fact, the FDA issued a warning to OTC lash serum makers back in 2011 about the potential dangers of including a synthetic version of a prescription product with known FDA-studied side effect profile in their formulations. Statements from companies claiming that they “contain no active medical ingredient” makes things all the more confusing for potential patients trying to do their due diligence if they know they have a previous diagnosis of dry eye or are at increased risk.

Here’s a list of the most popular OTC lash growth serums using synthetic prostaglandin analogues in their formulas:

  • Xlash Eyelash Enhancer
  • Neulash
  • NeuveauBrow
  • RevitaLash
  • Nutraluxe MD Lash
  • M2 Lashes Eyelash activating serum
  • Peter Thomas Roth Lashes to die for Platinum
  • Rodan and Fields Lash Boost


Take Home
: If you have chronic dry eye, or experience any increase in redness, watering, or eye irritation using these products, understand that you may be causing permanent damage to your delicate tear film and ocular surface. Listen to your body and discontinue use immediately if you experience any symptoms. There is a major push within the medical community to have the FDA put stronger regulations on beauty products that are using chemicals with known side effects without disclosing the risks involved, but regulation and oversight may be many years away. Just because a product is over the counter, doesn’t mean that it is safe.  Make sure you read the ingredients closely on all cosmetic and facial products that you use, and if you spot Isopropyl Cloprostenate in any product you are using around your eyelid, consider that lasting dry eye issues could result as a side effect.